创伤性脑损伤的血液生物标志物:对当前证据的叙述性审查
Iftakher Hossain1,2,3, Niklas Marklund4, Endre Czeiter5
1Neurocenter, Department of Neurosurgery, Turku University Hospital, Turku, Finland.
Brain & spine
|March 21, 2024
概括
基于血液的生物标志物 (BBBM) 测试在创伤性脑损伤 (TBI) 诊断和结果预测方面表现有前途. GFAP和UCH-L1已获得FDA批准,而GFAP,S100B和NF-L对TBI诊断有很大的希望.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物发现发现
- 临床诊断 临床诊断 临床诊断
背景情况:
- 创伤性脑损伤 (TBI) 管理从准确的患者分层和结果预测中受益.
- 基于血液的生物标志物 (BBBM) 测试提供了一种非侵入性的方法来帮助评估TBI.
- 目前对TBI的诊断和预后工具存在局限性.
研究的目的:
- 审查BBBM在TBI中的临床应用的现有证据.
- 确定用于TBI诊断和预后的有希望的BBBM.
- 建议未来的方向,以推进TBI中的BBBBM研究.
主要方法:
- 从PubMed,Scopus和ISI知识网络中对文学进行叙事审查.
- 搜索术语包括"创伤性脑损伤"与"血液生物标志物"",诊断"",结果预测"",外损伤"和"测试方法"相结合.
主要成果:
- 状纤维酸蛋白 (GFAP) 和Ubiquitin C-终端酶-L1 (UCH-L1) 已获得FDA批准用于轻度TBICT检测.
- S100B应用减少了头部CT扫描;GFAP可以预测MRI异常.
- UCH-L1,S100B,神经纤维光 (NF-L) 和总tau在预测死亡率或不良结果方面具有价值,尽管在轻微的TBI中价值较低.
结论:
- GFAP,S100B和NF-L是TBI诊断的有希望的生物标志物.
- 需要进行大规模的研究,以探索BBBM动力学和在不同临床群体中的效用.
- 测试开发和交叉验证对于TBI BBBM结果的概括性至关重要.
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