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高强度运动通过产生氧化应激会损害肠道屏障功能,从而产生氧化应激.

Maki Takami1, Wataru Aoi1, Karin Matsumoto1

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高强度运动增加了肠道的透性,并通过氧化应激破坏了肠道屏障. 这种效应被一种丁氧化酶抑制剂逆转,这表明氧化应激在运动诱导的肠道问题中起着关键作用.

关键词:
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科学领域:

  • 生理学 生理学 生理学
  • 运动科学 运动科学
  • 胃肠病学 胃肠病学

背景情况:

  • 肠道充当了对有害物质的关键屏障.
  • 氧化损伤和粘膜损伤可能会损害这种屏障功能.
  • 运动引起的氧化应激对肠道透性的影响仍然不完全理解.

研究的目的:

  • 为了研究氧化应激在高强度运动后肠道屏障功能障碍中的作用.
  • 为了检查强度运动对小鼠内皮膜的透性的影响.

主要方法:

  • 雄性ICR小鼠接受了一次高强度跑步机跑步.
  • 皮质组织分析了组织学和生化变化.
  • 通过使用光素 (fluorescein isothiocyanate-dextran) 和血光强度来评估肠道透性.

主要成果:

  • 运动增加了肠道透性,体现在运动后更高的血光强度.
  • 在运动组中观察到氧化蛋白水平升高和克劳丁-1 (紧接蛋白) 降低.
  • 一种丁氧化酶抑制剂缓解了运动诱导的肠道透性的增加.
  • 两周的过度炼训练导致肠道透率提高,即使在休息状态下也是如此.

结论:

  • 高强度的运动会增加肠道的透性,并损害紧密的结节.
  • 氧化应激似乎是运动引起的肠道屏障破坏的关键媒介.
  • 向丁氧化酶可能提供一种策略,以管理与运动相关的肠道透性问题.