杆菌感染和肝硬化的并发症
Shefali Amin1, Biraj Shrestha2, Ameya Deshmukh3
1Internal Medicine, Tower Health Medical Group, Reading, USA.
这项研究发现,患有肝硬化和Helicobacter pylori (H. pylori) 感染的患者在医院死亡率较低,但并发症率更高,住院时间更长. 需要进一步的研究来澄清H. pylori在肝硬化结果中的作用.
科学领域:
- 胃肠病学和肝病学
- 传染性疾病 传染性疾病
- 临床结果研究研究
背景情况:
- 杆菌 (H. pylori) 与各种胃肠道疾病有关,新出现的证据表明与肝硬化有关.
- 杆菌对住院患者的结局,死亡率和肝硬化患者的并发症的影响仍然不完全理解.
- 鉴于H. pylori的流行率和有效的根除疗法的可用性,调查这种关联至关重要.
研究的目的:
- 检查H. pylori感染和诊断为肝硬化患者的住院治疗结果之间的关系.
- 在住院期间评估H. pylori与肝硬化相关并发症的关联.
- 评估H. pylori对肝硬化患者死亡率,住院时间和医疗费用的影响.
主要方法:
- 从2016-2019年对国家住院样本 (NIS) 数据库的回顾性分析.
- 纳入标准:初级诊断为肝硬化和二次诊断为H.pylori感染的患者.
- 主要结局:住院死亡率,住院时间,护理费用. 二次结局:与肝硬化相关的并发症 (例如,胃肠道出血,肝脑病,肝综合征).
主要成果:
- 在416,410名肝硬化患者中,990名 (0.2%) 患有H. pylori. 感染H. pylori的患者年轻,更有可能是男性,西班牙裔或黑人.
- 受H. pylori感染的患者在医院住院死亡率较低 (0.51%vs. 4.44%),但住院时间较长 (6.97vs. 5.75天).
- 暴露于H. pylori与整体肝硬化并发症 (84.85%与67.59%) 的显著更高率,胃肠道出血和肝综合征有关.
结论:
- 虽然肝硬化患者的H. pylori共感染与较低的死亡率有关,但与增加的并发症率和更长的住院时间相关.
- 这项研究强调了相关性,但无法确定H. pylori和肝硬化并发症之间的因果关系.
- 需要进一步的研究来阐明H. pylori在肝硬化结果中的复杂关系和潜在的致病作用.
更多相关视频
04:00Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
Published on: November 15, 2024
09:05High Resolution Electron Microscopy of the Helicobacter pylori Cag Type IV Secretion System Pili Produced in Varying Conditions of Iron Availability
Published on: November 21, 2014
相关概念视频
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
