在严重抑郁症中,异常的默认模式网络同质性和睡眠障碍之间的关联
Muzhi Huang1, Yangpan Ou1, Huabing Li2
1Department of Psychiatry, The Second Xiangya Hospital of Central South University National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, Changsha, Hunan, China.
严重抑郁症 (MDD) 与睡眠障碍一起显示出改变的默认模式网络 (DMN) 同质性. 前额叶皮质和前皮质的DMN变化可能表明MDD和睡眠问题背后的神经生物学机制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 睡眠障碍是主要抑郁障碍 (MDD) 的常见并发症.
- 在睡眠障碍的MDD患者中,默认模式网络 (DMN) 网络同质性 (NH) 的变化尚不清楚.
研究的目的:
- 在患有睡眠障碍的MDD患者中调查异常的DMN NH.
- 根据DMN NH.区分睡眠障碍的MDD与没有睡眠障碍的MDD,以DMN NH.
主要方法:
- 招募了24名患有MDD和睡眠障碍的患者 (Pa_s),33名没有睡眠障碍的MDD患者 (Pa_ns) 和32名健康对照 (HCs).
- 使用网络同质性 (NH) 度量分析了静止状态功能成像数据.
主要成果:
- 与患者和HC相比,患者在左上中间前额叶皮质的NH减少,右前额叶皮质的NH增加.
- 在左上中间前额叶皮层NH和睡眠障碍严重程度之间发现了显著的负相关性 (r=-0.42,p=0.001).
- 在右前性NH和睡眠障碍严重程度之间观察到显著的正相关性 (r=0.41,p=0.002).
结论:
- 带有睡眠障碍的MDD的特征是异常的DMN NH.
- DMN NH 变化可以区分患有睡眠障碍的MDD患者和没有睡眠障碍的MDD患者.
- 该DMN涉及到MDD与睡眠障碍并发症的神经生物学基础.
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