周围动脉疾病:一个小和大血管问题.
Monique Bethel1, Brian H Annex1,2
1Department of Medicine, Division of Cardiology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
概括
周围动脉疾病 (PAD) 很常见,但诊断不足. 研究强调了超出大血管动脉样硬化之外的微血管功能障碍和复杂的病理生理学,需要新的治疗方法以获得更好的患者结果.
科学领域:
- 血管医学 血管医学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 周围动脉疾病 (PAD) 是系统性动脉样硬化的常见表现,经常被诊断不足和治疗不足.
- PAD显著影响心血管结果,无论间歇性音 (IC) 等症状如何.
- 目前对PAD的理解正在发展,超越大血管疾病,包括微血管功能障碍.
研究的目的:
- 强调PAD复杂的病理生理学,包括微血管和细胞变化.
- 突出有效治疗方法的不足利用情况,如监督炼和医疗治疗.
- 倡导研究基于对PAD的全面理解的新疗法.
主要方法:
- 审查目前对PAD病理生理学的理解.
- 分析现有的诊断和治疗策略的局限性.
- 最近关于微血管对PAD的贡献的研究结果的综合.
主要成果:
- PAD不仅涉及大血管动脉样硬化;微血管异常是关键的.
- 肌肉纤维化,神经病变和细胞功能障碍有助于PAD并发症.
- 监督运动训练是有效的,但它的机制和广泛使用是有限的.
结论:
- 对PAD病理生理学的整体观点,包括微血管和细胞方面,是必不可少的.
- 需要改进诊断和利用运动和医疗疗法.
- 为了开发有效的PAD治疗方法,进一步的研究至关重要.
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