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巴伊卡林可以改善肉肠道屏障功能和肠道微生物群
Shuangxiu Wan1,2, Linzheng Wang3, Zhili Hao4
1Shanxi Key Lab for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, China.
Acta biochimica et biophysica Sinica
|March 21, 2024
概括
拜卡林通过逆转脱氧尼瓦伦醇 (DON) 损伤和恢复有益的肠道细菌来改善肠健康. 这项研究表明baicalinalin.
科学领域:
- 动物科学动物科学
- 微生物学 微生物学
- 毒理学 毒理学 毒理学
背景情况:
- 料中的脱氧尼瓦伦 (DON) 污染会损害的肠道屏障功能,破坏微生物群,降低生长性能,导致经济损失.
- 了解天然化合物对DON毒性的保护作用对于家禽业至关重要.
研究的目的:
- 研究贝卡林对肉肠道屏障损伤和DON诱导的肠道微生物群失调的改善作用.
主要方法:
- 使用了150个Arbor Acres肉,分成组,接受了DON污染的料和不同剂量的baicalin.
- 评估了十二指肠,阴和阴的形态损伤.
- 评估了紧结蛋白 (ZO-1,克劳丁-1,奥克卢丁) 的表达,并分析了肠道微生物群的组成.
主要成果:
- 拜卡林治疗逆转了肉小肠中DON诱导的形态损伤.
- 在Baicalin治疗组中,紧结蛋白 (ZO-1,Claudin-1,Occludin) 的表达显著增加.
- 拜卡林改变了肠道微生物群,显著增加了像*Lactobacillus*这样的有益微生物,并减少了*Lachnospiraceae*.
结论:
- 贝卡林有效地改善肉肠道屏障功能,并减轻DON引起的损伤.
- 贝卡林的保护作用与肠道微生物组合的调节有关.
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