在早产新生儿中CPAP与NIPPV的后化:一项比较有效性研究
Amit Mukerji1, Brooke Read2, Junmin Yang3
1McMaster Children's Hospital, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
Pediatrics
|March 21, 2024
概括
鼻连续正气道压力 (CPAP) 在早产新生儿的初始模式失效方面并不优于鼻间歇性正压通风 (NIPPV). 然而,CPAP在72小时和7天内显示出对再输管率的非劣势.
科学领域:
- 新生儿的呼吸系统支持.
- 机械通风策略 机械通风策略
- 管术后的护理
背景情况:
- 鼻间歇性正压通风 (NIPPV) 通常被认为优于鼻持续正气道压力 (CPAP) 对于早产新生儿.
- 之前的研究限制了高CPAP压力或救援通风选项,可能会扭曲比较.
- 这项研究调查了CPAP是否可以在允许更高压力和救援通风的条件下与NIPPV无差.
研究的目的:
- 为了确定鼻腔CPAP (nCPAP) 是否不劣于NIPPV,作为早产新生儿 (<29周妊娠期) 的后化模式.
- 为了评估当允许更高的CPAP压力和救援通风时的结果.
- 为了比较nCPAP和NIPPV之间的初始模式故障和重新灌输率.
主要方法:
- 一项务实,比较有效性,非劣等性研究,使用来自22个加拿大NICU的真实数据.
- 这些中心自行选择了nCPAP或NIPPV作为标准的术后治疗模式.
- 主要结果:初始模式在72小时内失效. 二次结局:在7天内失败,并在72小时和7天内重新输管.
主要成果:
- 鼻腔CPAP在72小时内 (33.0%对26.3%) 和7天内 (40.7%对35.8%) 的初始模式失效方面并非低于NIPPV (并且低于NIPPV).
- 然而,鼻腔CPAP在72小时内重新输管时与NIPPV不差 (并且相当).
- 鼻腔CPAP在7天内重新输管时也与NIPPV不劣 (且优于NIPPV) (16.4%对22.8%).
结论:
- 鼻CPAP在预防早产新生儿初始模式失败后化方面并不比NIPPV差.
- 鼻腔CPAP在72小时和7天的时间表中表现出对再输管率的非劣势.
- 当有有效的救援通风选择时,鼻腔CPAP可能是一个可行的初始脱口术后策略.
相关概念视频
Mechanical Ventilation III: Noninvasive Ventilation
111
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
111
Endotracheal Tube Extubation
643
Endotracheal tube extubation is a critical procedure in weaning patients from mechanical ventilation. It involves physically removing the oral or nasal endotracheal (ET) tube, marking the final step in liberating a patient from ventilatory support.
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....
643
Endotracheal Intubation II: Nursing Management
619
Endotracheal intubation is a critical procedure that can be lifesaving for many patients with respiratory distress or failure. The role of nursing in managing endotracheal tubes is pivotal, as it involves pre-intubation preparation, assisting during the procedure, and post-extubation care.
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...
619
Mechanical Ventilation I: Indication and Settings
353
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
353
Mechanical Ventilation II: Invasive Ventilation
132
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
132
Endotracheal Intubation I: Procedure
1.2K
Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...
1.2K


