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Updated: Jun 30, 2025

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突变合成产生了九种新的pyrroindomycins.

Zhuhua Wu1,2, Zhengxiang Xia2,3, Zhijun Tang2

  • 1National key Laboratory of Lead druggability Research, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Copernicus Road, Shanghai 201203, China. liji_an@hotmail.com.

Organic & biomolecular chemistry
|March 21, 2024
PubMed
概括

研究人员使用突变合成方法产生了9种新的pyrroindomycins (PYR). 这种方法通过阻断特定的基因功能和提供化学前体来修改PYRs,扩大了这些强大的天然产品的多样性.

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
A key example involves the conjugation of cyanide ions, which impair cellular respiration and alter hemoglobin into non-oxygen-carrying cyanmethemoglobin. To neutralize this threat, a sulfur atom from thiosulphate is transferred to the cyanide ion, catalyzed by the enzyme rhodanese, resulting in an inactive compound called thiocyanate. The production of...
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