子宫内膜异位症风险和荷尔蒙避孕药的使用:一项全国性的队列研究
Cerisa Obern1, Matts Olovsson1, Tanja Tydén1
1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
概括
早期使用荷尔蒙避孕药 (HC) 和难以找到合适的方法是子宫内膜异位症的潜在警告信号. 然而,长时间使用HC与诊断风险降低有关.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 内分泌学 在内分泌学.
背景情况:
- 子宫内膜异位症是一种慢性疾病,影响生殖年龄的女性.
- 荷尔蒙避孕药 (HCs) 通常用于治疗妇科疾病.
- 识别子宫内膜异位症的早期预警信号对于及时诊断和管理至关重要.
研究的目的:
- 确定是否早期开始使用荷尔蒙避孕药 (HC) 或寻找合适的HC方法的挑战可以作为子宫内膜异位症的指标.
- 调查HC使用模式与子宫内膜异位症诊断风险之间的关联.
主要方法:
- 使用瑞典国家登记册进行了一项回顾性队列研究.
- 这项研究包括了2005年至2017年期间12-27岁的720805名女性.
- 统计分析包括计算调整的危险比率 (aHRs) 来评估风险,控制各种人口和健康因素.
主要成果:
- 在12-14岁之间开始使用HC的女性,与17岁以上开始使用HC的女性相比,患子宫内膜异位症的风险增加了2.53倍.
- 尝试超过三种类型的HC与2.31倍的风险增加有关.
- 一年多使用HC与子宫内膜异位症风险降低0.53倍有关.
结论:
- 早期使用HC和难以找到合适的方法被确定为子宫内膜异位症的潜在警告信号.
- 长时间使用HC (>1年) 显示有保护作用,降低了被诊断为子宫内膜异位症的风险.
- 与之相关的疾病,如经期不良,抑郁和不孕不育,在患有子宫内膜异位症的女性中更为普遍.
更多相关视频
07:20Intraoperative Detection of Subtle Endometriosis: A Novel Paradigm for Detection and Treatment of Pelvic Pain Associated with the Loss of Peritoneal Integrity
Published on: December 21, 2012
15.9K
09:20Generation of Multicellular Human Primary Endometrial Organoids
Published on: October 4, 2019
10.9K
相关概念视频
Hormonal Regulation of the Menstrual Cycle
354
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
354
Oogenesis
63.7K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.7K
Birth Control Methods
242
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
242
Disorders of the Female Reproductive System
357
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
357
Hormonal Control of the Ovarian Cycle
478
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
478
Ovarian Cycle
1.2K
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle...
1.2K
