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与布伦图西马布维多丁治疗相关的炎症性神经病变的发生率和特征
Arthur Matthys1,2, Benjamin Bardel3,4, Fabien Le Bras5
1Department of Neurology, AP-HP, Henri Mondor University Hospital, Créteil, France.
European journal of neurology
|March 21, 2024
概括
布伦图西马布维多丁诱导的炎症性神经病变 (BV-IN) 影响7.2%的患者,并表现为严重的虚弱和行走问题. 使用红旗的早期检测可以改善这种致残并发症的管理.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 周围神经病变是布伦图西马布维多丁 (BV) 的常见并发症,这是CD30+淋巴瘤治疗.
- 经典BV诱导的神经病变 (BV-CN) 通常是一种轻微的感官轴突多神经病变.
- 严重的BV诱导的炎症性神经病变 (BV-IN) 不太常见,但可以显著增加发病率.
研究的目的:
- 为了评估BV-IN. 的发病率.
- 识别与BV-IN.IN.相关的风险因素和警告标志.
- 开发一种算法,通过非神经学家的医生早期检测BV-IN.
主要方法:
- 在2014年4月至2021年9月接受BV治疗的患者的回顾性队列研究.
- 收集的数据包括临床,生物和电生理学参数.
- BV-IN定义使用适应的欧洲神经学会/外围神经学会2021年慢性炎症性脱髓化多基基隆性神经病变的标准.
主要成果:
- 83名患者中有49%患上神经病变;7.2%被归类为BV-IN (6名患者).
- 与BV-CN相比,BV-IN患者更频繁地出现肌肉衰弱,步态障碍和急性/次急性发作.
- BV-IN通常是严重的 (等级≥3),50%的BV-IN患者经历了这种情况.
结论:
- 布伦图西马布维多丁诱导的神经病变是一种未被认可的并发症.
- 四个易于识别的"红旗"可以帮助检测BV-IN.
- 基于这些红旗的算法旨在减少BV-IN的诊断和管理延迟.
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