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深度大脑刺激对治疗耐药抑郁症的不良影响:一个范围审查

Jorge D S Lapa^1,2, Joel F S Duarte³, Ana Carolina P Campos⁴

¹Department of Medicine, Federal University of Sergipe, Aracaju , Sergipe , Brazil.

|March 21, 2024

概括

对抗治疗性抑郁症 (TRD) 的深度大脑刺激 (DBS) 具有手术和精神病风险. 虽然出血和感染率是可以接受的,但恶化的抑郁,焦虑和躁狂需要仔细考虑.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经外科神经外科

背景情况:

深度大脑刺激 (DBS) 是治疗耐药性抑郁症 (TRD) 的新兴疗法.
对于TRD的DBS的整体安全概况尚未确立,通常被认为与运动障碍的DBS相似.

研究的目的:

为 TRD 汇集 DBS 上的现有安全数据.
在TRD患者中描述DBS的不良事件概况.

主要方法:

在PubMed的系统文献搜索中,搜索有关DBS的英语文章,寻找TRD的不良结果.
纳入标准:至少5名患者,至少6个月的随访.
从28篇关于353名患者的文章中提取和综合数据.

主要成果:

发生出血率:0.8%;感染率:10.2%.
完成自杀率: 2.5% 完成自杀率: 2.5%
抑郁症 (18.4%),焦虑症 (9.1%) 和躁狂症 (5.1%) 的发展/恶化.

结论:

对TRD的DBS与手术 (出血,感染) 和精神病不良事件有关.
自杀风险 (2.5%) 可能与TRD的自然过程保持一致.
恶化的抑郁,焦虑和躁狂发病率是需要承认的关键风险.

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