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Updated: Jun 30, 2025

Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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致病性LRRK2对RAB3的酸化损害了突触囊泡前体的贩运

Dan Dou1,2,3, Jayne Aiken1, Erika L F Holzbaur1,2,3

  • 1Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

The Journal of cell biology
|March 21, 2024
PubMed
概括

在帕金森病 (PD) 模型中,致病性LRRK2突变通过化RAB3A.破坏了突触囊泡运输. 这会损害到突触的蛋白质输送,导致PD的非运动和认知症状.

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