[中风后认知障碍的发展与血液静止的凝血成分变化之间的关系]
I A Koltsov1,2, I A Shchukin1,2, E A Kovalenko1,2
1Federal Center of Brain Research and Neurotechnologies, Moscow, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|March 21, 2024
概括
缺血性中风 (IS) 后纤维素凝块密度增加与认知功能恶化有关. 这一发现表明纤维素凝块光学密度可能作为中风后认知障碍 (PSCI) 的早期生物标志物.
科学领域:
- 神经学 神经学
- 血液学 血液学 血液学
- 生物标志物发现发现
背景情况:
- 脑卒中后认知障碍 (PSCI) 是缺血性中风 (IS) 的常见并发症.
- 早期识别患有PSCI风险的患者对于及时干预至关重要.
- 凝血异常可能在PSCI的发展中发挥作用.
研究的目的:
- 调查动态血栓光度学参数与PSCI的严重程度之间的关联.
- 确定凝血参数是否可以作为PSCI的早期生物标志物.
主要方法:
- 在中风后的10-14天,三十五名半球性IS患者使用蒙特利尔认知评估 (MoCA) 评估认知状态.
- 凝血参数,包括纤维素凝块光学密度 (D),在入院时使用动态血栓光度测量,在6-8天和13-15天测量.
- 数据与健康志愿者的对照组进行了比较.
主要成果:
- 虽然大多数空间和时间凝血参数保持在参考范围内,但纤维素凝块光密度 (D) 从入院到中风后的第一周和第二周显著增加 (分别p=0.007和p=0.009).
- 在6-8日和13-15日,较高的纤维素凝块光学密度 (D) 与较低的MoCA得分显著相关 (p<0.01).
- 这些发现表明,改变血液静止对IS患者的认知功能有负面影响.
结论:
- 缺血性中风后的早期几周内纤维素凝块光学密度 (D) 的升高是发展PSCI的潜在预后生物标志物.
- 动态血栓光度测试可以提供有关血静变化的宝贵见解,这些变化有助于中风后认知能力下降.
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