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Updated: Jun 30, 2025

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通过分子动力学模拟和机器学习来探索μ-阿片类受体的偏向激活特征

Jianfang Chen1, Qiaoling Gou1, Xin Chen1

  • 1College of Chemistry, Sichuan University, Chengdu 610064, China. xmpuscu@scu.edu.cn.

Physical chemistry chemical physics : PCCP
|March 21, 2024
PubMed
概括

偏差配体具有治疗潜力,但它们的激活机制尚不清楚. 这项研究使用分子动力学和深度学习来揭示由G蛋白和β-阿雷斯偏向激素诱导的mu-阿片类受体 (μOR) 中明显的构造变化.

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