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长期体重指数变化和不良心血管结果
Zakaria Almuwaqqat1,2, Qin Hui1,3, Chang Liu3
1Veterans Affairs Atlanta Healthcare System, Decatur, Georgia.
JAMA network open
|March 21, 2024
概括
高体重指数 (BMI) 的变化,或体重的波动,与心血管疾病 (CVD) 事件的风险增加有关. 这种关联在不同种族和种族群体中是正确的,而不依赖于平均BMI.
科学领域:
- 心血管疾病流行病学
- 肥胖研究的研究.
- 生物统计学 生物统计学
背景情况:
- 体重指数 (BMI) 是肥胖的一个关键指标,受遗传学和生活方式的影响.
- 显著的体重波动可能标志着不良的生物过程.
- 心血管疾病 (CVD) 仍然是全球主要的死亡原因.
研究的目的:
- 调查身体质量指数 (BMI) 变化与心血管疾病 (CVD) 事件发生率之间的关联.
- 在两个不同的大规模队列中分析这一关联:百万退伍军人计划 (MVP) 和英国生物银行 (UKB).
主要方法:
- 一个队列研究设计,利用MVP (2011-2018) 和UKB (2006-2010) 的数据.
- 用标准偏差和多次测量的变化系数来量化BMI变化.
- 使用考克斯的比例危险建模,根据已确定的心血管疾病风险因素进行调整,评估了事件组合心血管疾病事件.
主要成果:
- 在MVP队列中 (92,363名美国退伍军人),更高的BMI变化 (CV) 与16%的复合心血管疾病事件风险增加有关 (HR,1.16;95% CI,1.13-1.19).
- 这些发现在种族和种族子组之间是一致的,并且独立于平均BMI.
- 在UKB队列 (65,047人) 中,BMI变异性每增加1个SD与心血管死亡风险增加8%相关 (HR,1.08;95%CI,1.04-1.11).
结论:
- 较高的BMI变异性是心血管不良事件的重要,独立的风险标志物.
- 体重指数变化与心血管疾病风险之间的关联在不同人群和医疗保健系统中是一致的.
- 需要进一步的研究,以阐明BMI变化和心血管结果之间的联系背后的具体机制.
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