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Updated: Jun 30, 2025

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
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在小鼠生殖细胞中发生的Rad50-null突变会导致减少DSB的形成,异常的DSB末端切除和完全失去生殖细胞

Yuefang Liu1, Zhen Lin2, Junyi Yan2

  • 1School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China.

Development (Cambridge, England)
|March 21, 2024
PubMed
概括

在哺乳动物生殖细胞中,Rad50蛋白对DNA修复和基因组稳定性至关重要. 它的缺失会损害介质重组和DNA双链断裂 (DSB) 修复,导致生殖细胞的损失.

关键词:
拉德50 Rad50 拉德50 拉德50是什么意思在DSB末端切除术中.最后一个-seqqq.介质变化 (Meiosis) 是一个过程.精子干细胞 (Spermatogonial stem cells) 是一种精子干细胞.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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