主要与预防性抗发作药物预防在抗CD19CAR T细胞治疗中
Umberto Pensato1,2, Federica Pondrelli3,4, Chiara de Philippis5
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072, Pieve Emanuele, Milan, Italy. umbertopensato91@gmail.com.
概括
抗发作药物 (ASM) 预防对于接受抗CD19 CAR T细胞治疗的患者来说是安全有效的. 主要和预防性策略在预防发作方面表现相似,尽管初级预防可能会带来轻微的优势.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在抗CD19 CAR T细胞治疗后,多达30%的非霍奇金淋巴瘤患者患有发作.
- 预防的最佳抗药物 (ASM) 策略仍在研究中.
研究的目的:
- 在接受抗CD19 CAR T细胞治疗的患者中,比较初级预防与ASM预防性治疗的疗效和安全性.
主要方法:
- 一系列连续的156名患有耐火性非霍奇金淋巴瘤的患者接受了抗CD19CART细胞的分析.
- 患者被分为两组:在CAR T细胞输注之前开始的初级预防 (PP组) 和在神经毒性开始时开始的预防性治疗 (PET组).
主要成果:
- 神经毒性发生在29%的患者中,在PP组 (88名患者) 和PET组 (66名患者) 之间没有显著差异.
- 五名患者发生了发作 (2%在PP组,4%在PET组). 在PET组的发作没有明显的神经毒性,而PP组的发作与严重脑病变有关.
- ASM耐受性良好,没有患者患上或需要长期的ASM治疗.
结论:
- 用ASM进行的初级预防和预防性治疗都是安全有效的,可以预防抗CD19CART细胞接受者的发作.
- 虽然初级预防可能具有稍微更有利的概况,但该研究无法最终得出两个ASM策略之间的优越性结论.
关键词:
抗药物 抗药物 抗药物癌症免疫疗法癌症免疫疗法细胞因子风暴相关脑病变 (CySE)电脑电图 (EEG) 是一种电脑电图.免疫因子相关的神经毒性综合征 (ICANS)神经学并发症 神经学并发症神经毒性 神经毒性非霍奇金淋巴瘤非霍奇金淋巴瘤状态 性病 的状态更多相关视频
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