基于风险的乳腺查 (RIBBS) 研究协议:为年轻女性提供个性化查模型
Gisella Gennaro1, Lauro Bucchi2, Alessandra Ravaioli3
1Veneto Institute of Oncology (IOV) IRCCS, Padua, Italy.
La Radiologia medica
|March 21, 2024
概括
这项研究比较了一种新的风险分层乳房扫描查策略与45-49岁妇女的标准年检. 目标是确定个性化查是否可以降低晚期乳腺癌 (BC) 发病率.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 45-49岁女性的最佳乳房扫描查仍在争论中.
- 当前的查方案可能无法充分解决个体乳腺癌风险.
- 该RIBBS研究协议通过比较分层查与标准的年度数字造乳镜来解决这个问题.
研究的目的:
- 为了比较风险和乳腺密度分层查模型与年度数字造乳镜 (DM) 查.
- 评估45岁女性晚期乳腺癌 (BC) 的累积发病率.
- 在现实环境中评估个性化查协议的有效性.
主要方法:
- 一个准实验性的,前性的,基于人群的研究,比较干预队列 (风险分层) 与观察对照队列 (年度DM).
- 干预队列 (n=10,269) 使用体积乳腺密度 (VBD) 和Tyrer-Cuzick模型进行风险分层.
- 对照组 (n=43,000) 每年接受DM查.
主要成果:
- 干预队列使用了基于终身风险 (LTR) 和VBD的五种不同的查协议.
- 协议范围从每两年一次的DBT到每年一次的DBT,超声波或乳房MRI用于高风险个体.
- 该研究正在进行中,累计发病率将在3,5年和10年后进行比较.
结论:
- 该RIBBS研究协议为45-49岁女性的个性化乳房扫描查提供了一个框架.
- 这种风险分层的方法旨在优化乳腺癌的早期检测.
- 进一步的结果将阐明个性化查对晚期乳腺癌发病率的影响.
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