充电模式神经刺激器与电容重复使用残余电荷探测器和活性电荷平衡器用于发作抑制
IEEE transactions on biomedical circuits and systems
|March 21, 2024
概括
这项研究引入了一种用于抑制的先进充电模式神经刺激器,它采用了一种新的电容重复使用技术和残余电荷检测,用于精确,实时的缓解. 这项创新确保了主动电荷平衡和高集成,以实现有效的神经刺激.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 电气工程 电气工程
背景情况:
- 抑制系统需要精确可靠的电刺激.
- 现有的神经刺激器面临电路复杂性,晶体管电压耐受性和系统集成方面的挑战.
- 刺激参数的实时监测和控制对于有效的管理至关重要.
研究的目的:
- 提出和验证一种用于抑制的新型充电模式神经刺激器.
- 通过先进的刺激技术,在发作期间实现实时症状缓解.
- 通过电容重复使用和剩余电荷检测来增强系统集成和性能.
主要方法:
- 充电模式神经刺激器的设计,包括电容重复使用和剩余电荷探测器.
- 实施活性电荷平衡,以防止电极阻抗上的电荷积累.
- 使用TSMC 0.18μm 1P6M CMOS工艺进行制造.
- 通过动物实验验证,以抑制发作.
主要成果:
- 拟议的刺激器实现了主动电荷平衡,并利用电容重用来实现高集成.
- 剩余电荷探测器为参数优化提供实时刺激信息.
- 该设备以0.2127mm2的核心面积制造,并展示了准确的可编程刺激参数.
- 在动物模型中证实了抑制发作的有效性.
结论:
- 开发的充电模式神经刺激器为实时抑制提供了一个有希望的解决方案.
- 综合设计,包括电容重复使用和主动电荷平衡,提高性能和可靠性.
- 这项技术有可能对治疗发作障碍产生重大影响.
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