患有心力衰竭和减少射出分数的人群中肉类的患病率和影响 (SARC-HF研究):一项前性观察研究协议
Pablo Marino Corrêa Nascimento1,2, Luiz Fernando Rodrigues Junior1,3, Mauro Felippe Felix Mediano1,4
1National Institute of Cardiology, Rio de Janeiro, Brazil.
PloS one
|March 21, 2024
概括
这项研究调查了心力衰竭患者的萨尔科佩尼亚和迪纳佩尼亚,心脏衰竭患者的射出分数减少. 研究结果将这些情况与较差的结果,生活质量下降和身体能力下降联系起来.
科学领域:
- 老年学是一门学科.
- 心脏病学 心脏病学
- 肌肉生理学 肌肉生理学
背景情况:
- 标志着肌肉质量损失的萨尔科佩尼亚,对老年人的生活质量和生存有负面影响.
- 心力衰竭 (HF) 与左心室喷射率 (LVEF) 减少是一种严重的疾病,与高发病率和死亡率有关.
- 随着LVEF降低而同时出现的肉症和高血压可能会加剧患者的预后.
研究的目的:
- 根据最近的诊断标准,确定HF和减少LVEF的患者中萨尔科佩尼亚和/或迪纳佩尼亚的患病率.
- 为了比较HF患者和没有sarcopenia之间的基因和蛋白质表达.
- 评估萨尔科佩尼亚/迪纳佩尼亚与临床事件,生活质量,心肺功能和呼吸肌肉强度之间的关系.
主要方法:
- 使用麻症和生活质量评估问卷.
- 执行握手强度,步行速度,双能X射线吸收度和呼吸肌肉强度测试.
- 进行心肺运动测试,基因组和蛋白质组分析,并测量特定生物标志物 (NT-proBNP,GDF-15).
主要成果:
- 这项研究预计将在高血压患者中发现沙尔科佩尼亚/迪纳佩尼亚和不良临床结果之间的相关性.
- 预计在患有肉症和/或肌症的人群中,生活质量会降低.
- 假设心肺呼吸能力受损,呼吸效率和呼吸肌肉力量受损.
结论:
- 萨尔科佩尼亚和迪纳佩尼亚在LVEF降低的HF患者中很普遍,并且与较差的临床结果有关.
- 这些情况显著影响患者的生活质量和身体功能.
- 需要进一步研究分子机制和治疗性干预措施,以治疗HF中的肉症.
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