CT衍生的身体组成:在回顾性队列研究中与疾病,年龄和炎症的差异关联
Nicholas A Bradley1, Josh McGovern1, Ross D Dolan1
1Academic Unit of Surgery, University of Glasgow, Glasgow, United Kingdom.
PloS one
|March 21, 2024
概括
低骨肌密度在结肠直肠癌患者中比在腹腔大动脉动脉瘤患者中更常见. 在这两种情况下,年龄和系统性炎症显著影响骨肌肉质量和质量.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
背景情况:
- 低的骨肌肉质量和密度 (通过CT-身体组成评估) 对癌症和非癌症患者都有预后影响.
- CT-BC参数越来越多地被认为具有预测价值.
研究的目的:
- 为了比较非癌症 (腹腔大动脉动脉瘤 - AAA) 和癌症 (结肠直肠癌 - CRC) 患者队列之间的CT-BC参数.
- 研究这些队伍中年龄和全身炎症与骨肌肉参数的关联.
主要方法:
- 两个多中心队列的回顾性比较:AAA (n=759) 和CRC (n=936).
- 对内脏脂肪区域 (VFA),骨脂肪指数 (SFI),骨肌指数 (SMI) 和骨肌密度 (SMD) 的分析.
- 使用系统性炎症等级 (SIG) 评估系统性炎症反应.
主要成果:
- 低骨肌密度 (SMD) 在CRC队列 (66%) 与AAA队列 (33%) 相比显著更普遍.
- 低骨肌指数 (SMI) 的患病率在队列之间相似 (51%).
- 随着年龄的增长和SIG的升高,在两个队列中,SMI和SMD的几率都增加了. 诊断CRC和ASA> 2也与低SMD相关.
结论:
- 年龄和全身炎症是骨肌肉质量和质量损失的关键决定因素.
- 这些因素似乎会影响肌肉健康,而不论是潜在的疾病 (AAA与CRC).
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