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Updated: Jun 30, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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RUNX1 C端突变通过扰乱特定的增强剂-促进剂网络,损害血细胞分化

Nathan D Jayne1,2, Zhengyu Liang3, Do-Hwan Lim3

  • 1Moores UCSD Cancer Center, University of California San Diego, La Jolla, CA.

Blood advances
|March 21, 2024
PubMed
概括

在其DNA结合域之外的RUNX1突变可以产生破坏血细胞发育的蛋白质. 这些RUNX1突变通过新的机制失调血液形成,与简单的基因沉默不同.

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