PD1抑制细胞骨相关蛋白质的PKCθ依赖酸化和免疫突触形成

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Updated: Jun 30, 2025

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
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Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

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Daniela Chmiest1, Silvia Podavini1, Kalliopi Ioannidou2

  • 1Department of Immunobiology, University of Lausanne, Epalinges, Switzerland.

Blood advances
|March 21, 2024
PubMed
概括

编程细胞死亡蛋白1 (PD1) 抑制通过阻断蛋白激酶Cθ (PKCθ) 和维丁酸化,影响T细胞功能. 这表明维门丁酸化水平可以预测对基于PD1的癌症免疫疗法的反应.

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