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通过一种超分子免疫性细胞死亡诱导剂来增强癌症治疗:一种色素向的NIR光激活......II) 金属循环

Le Tu¹, Chonglu Li^1,2, Qihang Ding³

¹National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, China.

Journal of the American Chemical Society

|March 21, 2024

概括

一种新的 (II) 金属循环,Ru1105,在深层瘤中有效触发免疫细胞死亡 (ICD). 这种近红外激活剂增强了抗瘤免疫力,并减少了副作用,为癌症治疗提供了有前途的新疗法.

科学领域:

超分子化学超分子化学
材料科学材料科学材料科学
免疫治疗是一种免疫疗法.

背景情况:

免疫性细胞死亡 (ICD) 对于抗癌疗法至关重要.
在深层瘤中以最小的副作用刺激强大的免疫反应仍然是一个重大挑战.

研究的目的:

引入一种新型的近红外光激活自组装金属循环,Ru1105,作为一个超分子ICD诱导器.
评估其在增强免疫调节反应和减少深层瘤不良影响方面的有效性.

主要方法:

开发了一种通过近红外 (NIR) 光激活的Ru(II) 超分子金属循环 (Ru1105).
在体外和体内评估ROS生成,瘤透,细胞吸收和ICD诱导.
与oxaliplatin进行ICD疗效和剂量反应的比较.

主要成果:

Ru1105证明了深度激活的ROS生产 (~1厘米),具有抗扩散和抗ROS火的抵抗力.
在癌细胞和多细胞瘤球体中有效的细胞吸收和ROS生成.
与酸 (300微米) 相比,Ru1105在超低剂量 (10微米) 中诱导了更高效的ICD.
在体内研究显示,Ru1105引起了CD8+ T细胞反应和耗尽了Foxp3+ T细胞,副作用最小.

结论:

Ru1105是第一个Ru(II) 超分子ICD诱导剂,协同增强免疫调节反应.
它提供了一种强大而安全的基于金属的免疫疗法策略,用于对抗深层瘤.

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