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一种基于丝的水凝,含有德克萨米他和脂酸微晶,可局部输送到内耳

Haixia Xiong¹, Peili Zhang¹, Dongcheng Wang²

¹Department of Otolaryngology, School of Medicine, South China University of Technology, Guangzhou 510006, China; Department of Endoscopic Ear Surgery, Senior Department of Otorhinolaryngology Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing 100048, China.

Colloids and surfaces. B, Biointerfaces

|March 21, 2024

概括

在纤维蛋白水凝中使用组合药物微晶的局部药物递送显示了治疗听力损失的潜力. 虽然药理动力学与悬浮剂相似,但水凝配方显示出良好的生物相容性,并为感觉神经听力损失治疗提供了一个有前途的方法.

科学领域:

生物医学工程生物医学工程
药物输送系统药物输送系统
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

当地药物输送绕过了血液迷宫屏障,用于听力损失治疗.
组合药物微晶 (MCs) 通过入耳膜 (IT) 注射为感官神经听力损失提供了优势.
丝纤维素 (SF) 水凝可以提供持续的药物释放和粘性效应.

研究的目的:

为了研究非球形甲 (DEX) 和酸 (LA) MCs的制药特性,它们被纳入了用于IT的SF水凝中.
与药物MC悬浮剂相比,评估SF水凝配方的药理动力学,生物降解和生物相容性.
探索这种新配方在治疗听力损失方面的潜力.

主要方法:

通过沉制备非球形DEX和LA MCs.
在SF水凝中加入MC (SF+DEX+LA).
在海豚中注射SF+DEX+LA和DEX+LA悬浮液,然后进行药理动力学,生物降解和生物相容性评估.

主要成果:

与DEX+LA悬浮组相比,SF+DEX+LA水凝组的药理动力学没有显著改善.
MCs的非球形状和沉积效应可能解释了药理动力学发现.
耳组织表现出良好的形态,在两组中都没有显著的炎症反应.

结论:

组合MC悬浮液,没有载体,在听力损失治疗的准备和生物相容性方面具有优势.
这种配方显示出实际应用在本地药物输送听力损失的承诺.
进一步的研究可能会优化水凝配方,以改善药物输送和治疗结果.

关键词:

德克萨米他是一种内部耳朵的交付.脂酸酸是什么意思脂酸是什么意思非球形的微晶体.丝的水凝是丝的水凝

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