在患有胃肠道恶性瘤的老年人中,身体组成和生存率的种族差异
Gabriel F P Aleixo1, Daniel L Hess2, Mackenzie E Fowler3
1University of Pennsylvania, Department of Hematology and Oncology, Philadelphia, PA, United States of America.
Journal of geriatric oncology
|March 21, 2024
概括
身体构成,如萨科佩尼亚,影响了患有胃肠道癌症的黑人患者的生存率. 新的种族特异性切断揭示了萨科佩尼亚和骨髓炎与这个群体的生存率较差有关.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 健康差异 在健康上的差异
背景情况:
- 计算机断层扫描 (CT) 扫描可以量化肌肉和脂肪组织,预测化疗毒性和胃肠道 (GI) 癌症的生存率.
- 大多数先前的研究都集中在白人患者身上,因此在少数种族群体中身体成分的作用尚不清楚.
研究的目的:
- 调查肠胃恶性瘤患者身体组成和生存时间的种族差异.
- 为了提高预后准确性,开发特定种族的身体组成切断值.
主要方法:
- 一项前性队列研究分析了540名胃肠道恶性瘤患者的L3段CT图像 (24%NH-黑色).
- 骨肌肉指数 (SMI) 和骨肌肉辐射密度 (SMD) 被计算出来.
- 考克斯模型评估了身体构成对生存的影响,并提出了新的种族特异性切断.
主要成果:
- 在NH-黑人患者中,SMI减少5cm2/m2增加了全因死亡风险 (HR 1.25).
- 现有的肉症/骨髓炎切断线无法预测存活率.
- 新的种族特异性切断结果显示,患有肉症 (HR 2.31) 或肌骨瘤 (HR 2.63) 的NH-黑人患者的生存率明显降低.
结论:
- 非西班牙裔非西班牙裔黑人老年患者患有胃肠道癌症,患有肉症或骨髓炎,总体存活率较低.
- 对特定种族的身体组成评估对于在不同患者群体中准确预后至关重要.
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