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松动神经刺激缓解心脏功能障碍和炎症标记在老鼠心力衰竭期间

Misty M Owens¹, Suman Dalal², Aleksandra Radovic¹

¹Department of Biomedical Sciences, East Tennessee State University, Stanton-Gerber Hall, 178 Maple Ave., P.O. Box 70582, Mountain Home, TN, 37684, United States of America.

Autonomic neuroscience : basic & clinical

|March 21, 2024

概括

迷你神经刺激 (VNS) 疗法改善了心脏功能,并减少了小鼠心力衰竭模型中的不良重塑. 此外,VNS还减轻了中枢神经炎症,证明了其潜在的治疗益处.

科学领域:

心血管医学心血管医学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

减少喷射分数 (HFrEF) 的心力衰竭是一个日益严重的临床问题.
神经刺激 (VNS) 正在作为HFrEF的新治疗方法进行研究.
在HFrEF中VNS对心脏功能,重塑和中央神经炎症的影响仍然不完全理解.

研究的目的:

为了研究VNS对心脏功能,心脏重塑和中枢神经炎症的治疗效果,在HFrEF的压力过载 (PO) 鼠标模型中.
为了确定早期的VNS干预是否可以恢复HFrEF中的多器官平衡.

主要方法:

雄性Sprague-Dawley大鼠接受了压力过载手术,以诱导HFrEF.
在60天内给PO大鼠 (20Hz,1.0mA) 进行神经刺激 (VNS).
评估了心脏功能,心脏重塑 (过度缩,纤维化,亡) 和中央神经炎症 (微质激活).

主要成果:

VNS疗法缓解了PO诱导的中风体积和射出分数的减少,并使左心室尺寸正常化.
VNS逆转了PO诱导的肌细胞大小增加,心肌纤维化和亡.
VNS显著减轻了对心室内核和心室内核的微质激活.

结论:

早期的VNS疗法有效地恢复心脏功能,并在PO诱导的HFrEF大鼠模型中逆转不良心脏重塑.
通过减少与HFrEF相关的中央神经炎症,VNS表现出神经保护作用.
通过VNS补充活动有望恢复HFrEF的多器官平衡.

关键词:

心脏过度缩小的情况.心脏衰竭是因为心脏衰竭.神经炎症是一种神经炎症.压力过载的压力过载鼠标鼠标鼠标鼠标阴道神经刺激的刺激

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