Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Does insulin bolster antioxidant defenses via the extracellular signal-regulated kinases-protein kinase B-nuclear factor erythroid 2 p45-related factor 2 pathway?

Antioxidants & redox signaling·2011
Same author

Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy.

Diabetes research and clinical practice·2011
Same author

JAMIE: A software tool for jointly analyzing multiple ChIP-chip experiments.

Methods in molecular biology (Clifton, N.J.)·2011
Same author

Morphine-induced conditioned place preference in mice: metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry.

Analytica chimica acta·2011
Same author

[The interventions effect-assessment of the workers exposed to N, N-dimethylformamide by percutaneous in a synthetic leather factory].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases·2011
Same author

[The analysis of effect of Th1/Th2 cytokine in the different prognosis in severe influenza A (H1N1)].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology·2011

相关实验视频

Updated: Jun 23, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K

CTPredictor:通过整合来自单细胞Hi-C数据的多尺度特征来预测细胞类型的全面和强大的框架.

Zhenqi Shi1, Hao Wu1

  • 1School of Software, Shandong University, 250100, Jinan, China.

Computers in biology and medicine
|March 21, 2024
PubMed
概括

CTPredictor通过整合多尺度染色体组织特征,准确地从单细胞Hi-C数据中预测细胞类型. 这种计算方法增强了3D基因组结构分析和对细胞功能的理解.

科学领域:

  • 基因组学就是基因组学.
  • 计算生物学 计算生物学
  • 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

  • 单细胞Hi-C (scHi-C) 显示了3D染色体组织的可变性.
  • 在scHi-C数据集中准确地识别细胞类型是具有挑战性的.
  • 这阻碍了全面的基因组结构和功能研究.

研究的目的:

  • 开发一种先进的计算方法,使用scHi-C数据准确预测细胞类型.
  • 改进对3D基因组结构及其功能影响的分析.

主要方法:

  • 介绍CTPredictor,一种新的计算方法.
  • 多尺度特征的整合:SICP,SSICP和SBCP.
  • 开发一种融合分类模型,以提高预测准确度.

主要成果:

  • CTPredictor显著提高了scHi-C数据上的细胞类型预测准确度.
  • 基准测试证实了与现有方法和传统机器学习方法相比的强大性能.
  • 该方法显示了各种数据集的强大潜力.

结论:

关键词:
3D基因组结构是3D的预测细胞类型的预测.多个尺度的特征具有多个尺度.单细胞Hi-C数据 单细胞Hi-C数据

更多相关视频

Capturing Chromosome Conformation Across Length Scales
10:15

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

3.4K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

709

相关实验视频

Last Updated: Jun 23, 2026

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues
10:12

Droplet Barcoding-Based Single Cell Transcriptomics of Adult Mammalian Tissues

Published on: January 10, 2019

18.5K
Capturing Chromosome Conformation Across Length Scales
10:15

Capturing Chromosome Conformation Across Length Scales

Published on: January 20, 2023

3.4K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

709
  • CTPredictor是scHi-C数据中细胞类型预测的先进工具.
  • 该方法有助于更深入地了解3D基因组组织及其功能相关性.
  • CTPredictor支持在各种生物过程中进行更广泛的研究.