意大利NPS-EQA第二部分:在意大利的外部质量评估计划中拥有四年的经验,用于在头发中分析经典和新型精神活性物质
Maria Concetta Rotolo1, Silvia Graziano1, Maria Rosaria Varì1
1National Centre on Addiction and Doping, Istituto Superiore di Sanità, Rome, Italy.
Journal of pharmaceutical and biomedical analysis
|March 21, 2024
概括
意大利国家卫生研究院
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
背景情况:
- 在2019年建立了外部质量评估 (EQA) 计划.
- 专注于古典和新型精神活性物质 (NPS) 的头发测试.
- 涉及国家预警系统的合作中心.
研究的目的:
- 在头发测试中评估实验室性能.
- 评估滥用药物和NPS测试准确性的演变.
- 提高法医毒理学结果的可靠性.
主要方法:
- 准备了11个头发样本,已知度的古典和NPS.
- 包括3个空白样本用于质量控制.
- 评估了定性 (假阳性/假阴性) 和定量 (不准确性,准确性,Z分数) 数据.
主要成果:
- 在四轮 (2019-2023) 中,观察到减少虚假负 (52.4%至34.3%) 和虚假阳性 (55.0%至30.8%) 结果的显著改善.
- 对于NPS确定,最初的高错误率 (平均ERR% 6.2%-112.8%) 在随后的回合 (10.4%-22.4%) 显著改善.
- 平均变化系数 (CV%) 约为41.5%,令人满意的结果在12.0%至56.6%之间.
结论:
- 环境质量评估计划对于识别和纠正实验室错误至关重要.
- 持续参与提高了心理活性物质的头发测试的准确性和可重复性.
- 该计划展示了经典和新型精神活性物质检测实验室性能的进展.
相关概念视频
Nursing Evaluation
4.1K
The evaluation stage signals the end of the nursing process. The nurse gathers evaluative data to assess whether or not the patient has attained the expected results. Whereas the nurse collects data in the nursing assessment to identify the patient's health concerns, the evaluation stage data determines if the indicated health issues are resolved. Evaluative data collection includes two sections: the data acquired to evaluate patient outcomes and the time criteria for data collection.
4.1K
Quality Assurance
4.0K
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
4.0K
Qualitative Analysis
1.7K
Qualitative analysis is the process of identifying elements, ions, or compounds in an unknown sample. It is the first and most fundamental type of analysis based on the hierarchy of analytical goals. This hierarchy is significant as it provides a structured approach to scientific research, with qualitative analysis serving as the initial step, providing essential information before moving on to quantitative or other forms of analysis.
There are two main approaches to qualitative analysis:...
There are two main approaches to qualitative analysis:...
1.7K
Traits and States
886
Personality traits represent consistent patterns in behavior, thoughts, and emotions, reflecting an individual's tendencies across various situations. For example, extraversion, a well-known trait, manifests in individuals as talkative, energetic, and enthusiastic behaviors. These traits are stable over time, offering a reliable framework for predicting how people might act in different contexts. However, they do not define every moment of an individual's life. In contrast to traits,...
886
Self-Report Tests of Personality
1.3K
Self-report inventories are objective personality assessments that use multiple-choice items or numbered scales, typically ranging from 1 (strongly disagree) to 5 (strongly agree). They are often called Likert scales after Rensis Likert. These inventories are widely used due to their ease of administration and cost-effectiveness. One of the most prominent examples is the Minnesota Multiphasic Personality Inventory (MMPI), initially developed in the 1940s to assess abnormal personality traits.
1.3K
Self-Esteem
382
Self-esteem, a core aspect of psychological well-being, reflects an individual's positive and negative self-evaluation in terms of worth, competence, and overall value. It is both a stable trait and a dynamic process, influenced by experiences and social interactions across the lifespan. While global self-esteem offers a general assessment, research highlights that self-esteem is multidimensional and varies across specific life domains.Domain-Specific Self-EsteemResearchers have delineated...
382


