对不同类固醇用于入内注射的副作用进行比较
Yi Wang1, Jieli Zhao2, Juejing Wu1
1ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Hearing Medicine (Fudan University), Shanghai 200031, China.
American journal of otolaryngology
|March 21, 2024
概括
对于突然听力损失的内类固醇注射会引起不同的疼痛. 贝他美沙导致最严重的疼痛,而甲基prednisolone导致最长的疼痛持续时间.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 突发的感觉神经听力损失 (SSNHL) 经常被用内内膜 (IT) 类固醇注射来治疗.
- 选择类固醇及其度可能会影响治疗结果和副作用.
研究的目的:
- 为了比较不同的类固醇用于IT注射SSNHL的副作用,特别是疼痛和耳膜损伤.
主要方法:
- 160名SSNHL患者接受了六次IT注射.
- 根据类固醇类型/度,患者被分为四组:德克萨梅他松 (5mg/ml和10mg/ml),甲基prednisolone (40mg/ml) 和贝塔梅他松 (4mg/ml).
- 评估了疼痛的严重程度 (数值评分尺度) 和持续时间,头和 tympanic 膜状态.
主要成果:
- 在四组之间观察到疼痛严重程度和持续时间的显著差异 (p < 0.001).
- 贝塔梅他 (4mg/ml) 组报告了最高的平均疼痛得分 (6.03 ± 1.46).
- 甲基prednisolone (40mg/ml) 组经历了最长的疼痛持续时间 (31.93±15.20分钟).
结论:
- 在IT注射中使用的类型类固醇显著影响注射后的疼痛.
- 与德克萨米他配方相比,贝塔米他和甲基prednisolone似乎会引起更严重和更长时间的疼痛.
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