对2018年至2020年期间在英国监狱中扣押的药物浸纸张样本的分析
Asena Avci Akca1, Lewis Couchman2, Anca Frinculescu3
1Department of Biology, Akdeniz University, Antalya, Turkiye; Institute of Forensic Sciences, Department of Forensic Toxicology, Ankara University, Ankara, Turkiye; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
新型精神活性物质 (NPS) 在监狱中越来越令人担忧. 这项研究开发了一种在纸样本上识别NPS的方法,发现合成大麻素受体激动剂 (SCRA) 是最常见的,在监狱人口统计学中药物趋势各不相同.
科学领域:
- 法医化学 法医化学
- 毒理学 毒理学 毒理学
- 犯罪学 犯罪学
背景情况:
- 新型精神活性物质 (NPS) 经常在惩戒设施中遇到,通常伪装成通过vaping非法使用的浸纸.
- 了解监狱中NPS的流行和趋势对于有效的药物控制和安全管理至关重要.
研究的目的:
- 开发和验证一种定性分析方法,用于识别从囚犯处扣押的纸样上发现的各种NPS.
- 分析2018年至2020年期间英国监狱内毒品流行情况,并确定NPS流通的新兴趋势.
主要方法:
- 分析了12个英格兰监狱 (2018-2020) 的1250个被扣押的纸张样本.
- 样品的准备包括从小纸片中提取甲醇.
- 使用Q-TOF LC/MS (液体染色学-四极点飞行时间质谱) 进行NPS的定性鉴定.
主要成果:
- 合成大麻素受体激活剂 (SCRA) 是最频繁检测到的NPS组.
- 其他流行药物类别包括可卡因,海洛因类 (A),安非他胺类和胺类 (B) 物质.
- 毒品的流行因监狱类型而异:SCRA在男性监狱中占主导地位,海洛因类型 (A) 药物在女性监狱中更为普遍,低安全监狱的B类药物,普雷加巴林, gabapentin类型 (C) 和其他滥用/处方药的比例较高,而高安全设施主要含有尼古丁.
结论:
- 开发的LC/MS方法有效地在浸纸上识别NPS,提供了有关监狱中毒品使用的有价值数据.
- 调查结果揭示了与监狱人口统计和安全水平相关的不同毒品流行模式,有助于预测毒品趋势.
- 这项研究有助于了解毒品走私路线,并为监狱工作人员提供有关NPS流通的最新情报.
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