细胞溶液pH是环境线索与胰腺β细胞中的胰岛素处理和分泌的直接联系

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Updated: Jun 30, 2025

A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination
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A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

Published on: June 25, 2014

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Yujiang Fang1, Hexi Feng1, Bowen Zhang1

  • 1Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China; Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, Shanghai, China; Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai, China.

Cell metabolism
|March 21, 2024
PubMed
概括

胰腺β细胞中的细胞质pH (pHc) 与葡萄糖一起上升,激活Smad5,调节胰岛素分泌. Smad5 缺乏导致高血糖,而其调节改善了小鼠的葡萄糖不耐受性.

关键词:
这是Smad5的疯狂.这是一个V-ATPase.细胞溶液的pH值环境问题 环境问题胰岛素的加工和分泌过程.胰腺β细胞是什么

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