Wnt信号传递:调节与瘤相关的巨细胞和相关的免疫治疗见解
Yimeng Yuan1, Dapeng Wu1, Yifan Hou1
1Key Laboratory of Receptors-Mediated Gene Regulation and Drug Discovery, School of Basic Medical Sciences and Department of Urinary Surgery, Huaihe Hospital, Henan University, Kaifeng, China.
Biochemical pharmacology
|March 21, 2024
概括
癌症中Wnt信号通路至关重要,影响瘤相关巨细胞 (TAM) 和免疫反应. 针对Wnt信号提供了个性化癌症治疗和增强免疫疗法疗效的有希望的策略.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- Wnt信号通路是参与发育和组织平衡的基本保护级联.
- Wnt信号的失调与各种癌症的发病有关.
- 瘤微环境 (TME),包括瘤相关的巨细胞 (TAMs),在癌症进展和免疫规避中发挥着关键作用.
研究的目的:
- 审查Wnt信号通路在癌症中的多方面的作用.
- 阐明TME中Wnt信号传递,癌细胞和TAM之间的相互作用.
- 探索Wnt向治疗在癌症治疗和免疫治疗中的潜力.
主要方法:
- 关于癌症中Wnt信号的最近研究的文献综述.
- 分析Wnt途径对巨细胞极化和功能的影响.
- 检查Wnt信号传递在各种固体瘤和白血病中的作用.
- 评估当前和未来基于Wnt的治疗策略.
主要成果:
- Wnt信号促进巨细胞的成熟和透以进行免疫监测,但也推动TAM在TME中的免疫抑制表型.
- 癌细胞和TAM都使用Wnt信号进行通信,驱动致癌和各种癌症的进展.
- 与固体瘤相比,Wnt信号在白血病中表现出不同的作用.
- 新兴的Wnt向药物显示出增强抗癌免疫反应的潜力.
结论:
- Wnt信号传递是TME内的癌细胞-巨细胞相互作用的关键调节器.
- 准Wnt信号通路为新型癌症疗法提供了一个有希望的途径.
- 涉及Wnt信号调节器的组合疗法与传统或免疫疗法可以导致个性化癌症治疗策略.
相关概念视频
Canonical Wnt Signaling Pathway
8.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.7K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K


