在MR指导放射治疗中进行前列腺扩散权重成像 (DWI):对1.5T MR-Linac和1.5T MR模拟器进行可重复性评估
Oi Lei Wong1, Jing Yuan1, Darren M C Poon2
1Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong SAR, China.
Magnetic resonance imaging
|March 21, 2024
概括
扩散加权成像 (DWI) 显示前列腺癌放射治疗的希望. 这项研究发现MR模拟器和MR-Linac系统之间的明显扩散系数 (ADC) 值存在差异,这突显了需要仔细解释MRgRT中的DWI图像的需要.
科学领域:
- 放射治疗 物理与技术 放射治疗 物理与技术
- 医学成像和放射学医学成像和放射学
- 瘤学和癌症研究研究.
背景情况:
- 扩散权重成像 (DWI) 对于前列腺癌的图像导向放射治疗 (MRgRT) 是至关重要的.
- 挑战包括图像扭曲,文物和明显扩散系数 (ADC) 的可重现性.
- 在不同的1.5T系统中评估DWI质量和ADC可重现性对于临床实施至关重要.
研究的目的:
- 在1.5T MR模拟器和1.5T MR-Linac.上评估DWI图像质量和ADC可重现性.
- 为了比较来自ACR MRI幻影和接受MRgRT的前列腺癌患者的测量结果.
- 为了确定两个1.5T系统之间的ADC值的潜在系统差异.
主要方法:
- 在19名患者和ACRMRI幻体上进行了DW-MRI扫描,使用1.5TMR模拟器和MR-Linac.
- 在幻影中使用1D形状平度 (FL) 评估ADC均性.
- 图像质量,几何扭曲和ADC可重现性使用利克特尺度,定量测量和布兰德-阿尔特曼分析进行了评估.
主要成果:
- 这两种系统在幻影中都显示出高的ADC同质性 (FL>87.5%).
- 患者的图像质量得分是可以接受的,但前列腺内病变往往难以辨认.
- MR-Linac表现出更多的几何扭曲;在MR模拟器和MR-Linac之间发现了ADC值的显著差异 (p < 0.05).
结论:
- 在1.5 T MR模拟器和MR-Linac系统之间存在ADC值的系统差异.
- 在解释MR-Linac DWI时建议谨慎,因为偶尔会出现严重的工件.
- 需要进一步的研究来验证DWI和ADC作为前列腺癌MRgRT可靠的成像生物标志物.
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