185个国家的血液性恶性瘤诊断后死亡风险差异:全球数据分析
Jing Yang1, Xin Liu1, Qiu-Zi Zhong2
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cancer letters
|March 21, 2024
概括
血液性恶性瘤构成了全球卫生挑战. 在资源有限的地区,改善获得癌症药物的机会,特别是对弱势儿童来说,可以降低死亡风险.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 全球健康 全球健康
- 流行病学 流行病学
背景情况:
- 血液性恶性瘤 (HM) 构成了全球严重的健康负担.
- 了解死亡风险因素对于有效的公共卫生干预至关重要.
- 社会经济地位和获得治疗的机会显著影响癌症的结果.
研究的目的:
- 建立血性恶性瘤患者死亡风险的代理措施.
- 调查全球死亡风险与社会经济因素之间的关联.
- 探索死亡风险与获得必要的癌症药物之间的关系.
主要方法:
- 利用GLOBOCAN数据库进行发病率,死亡率和流行率数据 (2020年).
- 提取的社会经济数据:人类发展指数 (HDI),国民总收入 (GNI) 和脆弱性指数.
- 计算和年龄标准化的死亡率与患病率 (MPR) 和死亡率与发病率 (MIR).
- 使用Pearson相关性分析评估相关性.
主要成果:
- 2020年,全球HMs的发病率为1,278,362人,其中711,840人死亡.
- 全球年龄标准化的MPR和MIR分别为0.15和0.44.
- 根据地区,国家,HM类型和HDI组,MPR和MIR在不同地区,国家,HM类型和HDI组之间差异很大.
- 在老年人群中观察到更高的比率.
- 在MPR/MIR和HDI,GNI和癌症基本药物清单 (EML) 之间发现了负相关性.
- 在MPR/MIR和脆弱性指数之间发现了正相关性.
结论:
- 社会经济因素和获得必需药物的机会与血液性恶性瘤死亡风险密切相关.
- 在资源有限的地区进行有针对性的干预,专注于儿童等弱势群体是必不可少的.
- 改善获得癌症药物的机会可以在全球范围内减轻与HM相关的死亡率.
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