对多环芳的环境暴露:系统性红斑狼发病和进展的低估风险因素
Hui Jin1, Cheng Zhao1, Yiran Chen2
1Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences Institute of Dermatology, Nanjing, China; Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
环境中的多环芳 (PAH) 暴露,特别是来自生活方式的暴露,是系统性红斑狼 (SLE) 发病率的重要危险因素. 这项研究强调了PAH作为SLE发展的未被认可的贡献者.
科学领域:
- 环境健康 环境健康
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 系统性红斑狼 (SLE) 是一种具有复杂病因的慢性自身免疫性疾病.
- 环境因素越来越多地被认为是导致SLE病变的因素.
- 多环芳 (PAH) 是广泛存在的环境污染物,与各种不良健康结果有关.
研究的目的:
- 调查环境中的多环芳 (PAH) 暴露与系统性红斑狼 (SLE) 发病率之间的关联.
- 探索环境因素对SLE发病的影响中的人口变化.
- 在非职业暴露人群中,比较长期与短期PAH暴露生物标志物的可靠性.
主要方法:
- 一项涉及316名SLE患者和851名健康对照者的病例控制研究.
- 通过问卷进行环境暴露评估,按性别和年龄分层.
- 测量血清[a]二醇环氧化蛋白 (BPDE-Alb) 添加物和PAH度在血液样本从参与者的子集.
主要成果:
- 与生活方式相关的PAH暴露与SLE发病的关联比职业暴露更强,特别是在年轻女性中.
- 室内空气污染对SLE发病率产生了重大影响,与室外空气污染相当.
- 与健康对照组相比,SLE患者的PAH暴露水平和BPDE-Alb添加剂在SLE患者中逐渐更高,活跃SLE患者的水平显著增加.
结论:
- 环境中的PAH暴露,特别是来自生活方式来源的暴露,是SLE的重要且未被充分认识到的风险因素.
- 这些发现强调了在SLE病因和预防策略中考虑环境暴露的重要性.
- 长期暴露于PAH的生物标志物对于评估SLE患者等非职业暴露群体的风险非常有价值.
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