在患有1型糖尿病的青少年中持续进行中度和间歇性高强度运动:对失糖症有什么保护?
Cassandra Parent1, Elodie Lespagnol2, Serge Berthoin2
1Univ. Lille, Univ. Artois, Univ. Littoral Côte d'Opale, ULR 7369 - URePSSS - Unité de Recherche Pluridisciplinaire Sport Santé Société, 413 avenue Eugène Avinée 59120 LOOS, F-59000 Lille, France; Institut de Recherches Cliniques de Montréal, 110 Av. des Pins, Montréal, QC H2W 1R7, Canada.
Diabetes research and clinical practice
|March 21, 2024
概括
间歇性高强度有氧运动 (IHE) 可能比持续的中等强度运动 (CME) 更好地保护患有1型糖尿病 (T1D) 的儿童免受运动诱导的低血糖症. 这两种运动类型都是安全的,与不活动相比,不增加低血糖风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 运动医学 运动医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 运动对于管理1型糖尿病 (T1D) 从幼年起至关重要.
- 在有氧运动期间的低血糖是T1D儿童身体活动的重要障碍.
- 当前的运动建议可能与典型的儿童活动模式不完全一致.
研究的目的:
- 为了比较间歇性高强度有氧运动 (IHE) 与T1D儿童中持续性中等强度运动 (CME) 的血糖影响.
- 为了确定IHE是否模仿自发活动,提供更好的预防低血糖.
- 与不活动相比,评估这两种运动类型的安全性和血糖影响.
主要方法:
- 一项随机交叉研究,涉及12名患有T1D的儿童 (5名男孩,7名女孩) (平均年龄9.8岁).
- 参与者执行了基于ergo循环的CME和IHE协议,持续时间和机械负荷相同.
- 在运动期间和之后监测毛细血管和间歇性葡萄糖水平,并对基线血糖,碳水化合物摄入量和胰岛素水平进行调整.
主要成果:
- 间歇性高强度有氧运动 (IHE) 与持续的中等强度运动 (CME) 相比,减轻了1.47 mmol·L-1的运动诱导的毛细血管葡萄糖下降 (P <0.05).
- 在任何运动条件下都没有出现症状性低血糖发作.
- 持续的中等强度运动 (CME) 在早期恢复期间,与不活跃的日子相比,显示出对严重高血糖的暂时保护作用.
结论:
- 与CME相比,间歇性高强度有氧运动 (IHE) 在患有1型糖尿病的儿童中显示出在运动期间限制血糖下降的潜力.
- 无论是20分钟的CME和IHE协议都是安全的,并且不会在这个人群中增加低血糖的风险.
- 持续的中等强度运动 (CME) 可能在预防运动后高血糖症方面提供短期益处.
相关概念视频
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Diabetes Mellitus: Type 2 and Gestational
2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Insulin: Dosing Regimen and Adverse Effects
169
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
169
Diabetes: Symptoms, Diagnosis, and Complications
530
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
530
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Hypoglycemia and Glucagon
257
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
257


