Th2扭曲的外围T辅助细胞驱动B细胞在过敏支气管肺性阿斯伯吉洛症中
Rong-Guang Luo1,2,3, Yi-Fan Wu1,2,3, Hai-Wen Lu1,2,3
1Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
The European respiratory journal
|March 21, 2024
概括
偏向T-helper 2 (Th2) 的T-helper外围 (Tph) 细胞的升高在过敏支气管肺性阿斯伯吉洛症 (ABPA) 患者中被发现. 这些Tph细胞驱动免疫球蛋白E (IgE) 的产生,这表明它们是ABPA的潜在生物标志物和治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏研究 研究过敏
- T细胞生物学T细胞生物学
背景情况:
- 过敏性支气管肺性阿斯伯吉洛症 (ABPA) 具有反复恶化的特征.
- 在ABPA病原体中T细胞子集的确切作用仍然不完全理解.
研究的目的:
- 调查各种T细胞子集在ABPA中的参与.
- 为了确定与ABPA恶化和IgE产生相关的特定T细胞种群.
主要方法:
- 从ABPA患者,喘患者和健康对照患者的外周血液和支气管洗液 (BALF) 中对T助手类型1 (Th1),Th2,Th17,调节性T细胞 (Treg) 和介血素 (IL)-21+CD4+T细胞的流动细胞计分析.
- 在ABPA患者和对照人群中CD4+T细胞子集的RNA测序.
- 在体外共同培养实验中评估T细胞和B细胞相互作用和抗体产生.
主要成果:
- 与对照组相比,ABPA患者的Th2细胞增加,Th1和Th17细胞减少,Treg细胞数量相似.
- 一个独特的IL-5+IL-13+IL-21+CD4+T细胞群,称为外周T辅助细胞 (Tph),在ABPA患者的血液和BALF中显著增加.
- 在ABPA患者中,这些Tph细胞是Th2-歪曲的,表现出毛囊T辅助细胞特征,并在体外诱导了B细胞自主分化成产生IgE的等离子体.
结论:
- 在ABPA患者中,循环的Th2-歪曲Tph细胞的特定子集显著增加.
- 这些Tph细胞在驱动IgE产生方面发挥着至关重要的作用,这是ABPA的一个关键特征.
- 已识别的Tph细胞群体代表了管理ABPA的潜在生物标志物和治疗标.
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