在严重的COVID-19感染后1年内,尽管有持续的肺纤维化,但肺功能和运动耐受性得到改善
Claire F McGroder1, Mary M Salvatore2, Belinda M D'Souza2
1Medicine/Pulmonary, Allergy, and Critical Care Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Thorax
|March 21, 2024
概括
严重的COVID-19幸存者在住院15个月后,肺纤维化改善,并恶化了网膜. 像呼吸障碍这样的持续症状表明非呼吸道原因,需要持续监测肺部异常.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 严重的COVID-19可能导致长期的呼吸道并发症.
- 了解肺部异常和持续症状的进展对于患者的康复至关重要.
研究的目的:
- 在严重的COVID-19幸存者中评估长期肺和非肺结局.
- 在住院15个月后,调查放射检测结果与临床症状之间的关系.
主要方法:
- 对104名严重COVID-19幸存者的前性单中心队列研究.
- 在4个月和15个月的评估包括肺功能测试,6分钟的步行距离,握力,脆弱性评估和症状评估.
- 分析了放射性成像 (地面玻璃不透明度,纤维状网膜).
主要成果:
- 64%的幸存者在胸部成像上表现出纤维化模式.
- 肺功能,握力,6分钟的步行距离和脆弱性在15个月后正常化.
- 磨砂玻璃不透明度的改善与纤维状网络的恶化相关.
- 呼吸不全,咳和疲劳持续存在,与肺功能或放射性纤维化无关.
结论:
- 尽管有放射性纤维化,但在严重的COVID-19幸存者中,关键的生理措施正常化.
- 持续的症状表明非呼吸系统因素有助于长期的发病率.
- 长期监测间歇性肺异常是必要的,以预测未来的进展.
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