Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

68.2K
Overview
68.2K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

1.6K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.6K
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.7K
Humoral Immune Responses01:36

Humoral Immune Responses

72.7K
Overview
72.7K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Contribution of the Arg-33-His Replacement in the Histidine Kinase CpxA to Carbapenem and Cefiderocol Resistance in Serratia marcescens.

International journal of antimicrobial agents·2026
Same author

A Deep-Red-Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death.

Angewandte Chemie (International ed. in English)·2026
Same author

A Deep-Red-Absorbing Osmium(II)-Based Photosensitizer Evokes Pyroptosis by Targeting Glutamine Metabolism and Impairing Cell Redox Homeostasis.

Journal of the American Chemical Society·2026
Same author

Contribution of SHV-1 overexpression to carbapenem resistance in a Klebsiella pneumoniae clinical isolate.

The Journal of antimicrobial chemotherapy·2026
Same author

Progressive endothelial coverage enhances hemocompatibility and prevents calcification in bioprosthetic valve tissue.

Angiogenesis·2026
Same author

Repeated exposure to polyethylene microplastic mixtures containing PFAS and bisphenols activates THP-1 macrophages with inflammatory features.

Environmental pollution (Barking, Essex : 1987)·2026

相关实验视频

Updated: Jun 30, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.4K

在B组StreptococcusCC17高病毒性克隆和细胞之间的特定相互作用.

Anne-Sophie Bourrel1,2, Amandine Picart1, Jose-Carlos Fernandez1

  • 1Université Paris Cité, Institut Cochin, INSERM, U1016, CNRS, UMR8104, Paris, France.

Infection and immunity
|March 22, 2024
PubMed
概括

超病毒性B组链球菌 (GBS) CC17菌株与其他GBS菌株相比更容易被巨细胞结核,并且通过特定的表面蛋白质进行介导. 这种增强的相互作用可能有助于GBS CC17的持久性和传播.

关键词:
在CC17中,我们可以使用CC17.集团 BS 菌菌 菌链球菌的 agalactiaeae 是一个细菌.这就是THP-1的特点.粘附性 粘附性 粘附性 粘附性发酵细胞的形成 发酵细胞的形成

更多相关视频

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.7K
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.4K

相关实验视频

Last Updated: Jun 30, 2025

A Murine Model of Group B Streptococcus Vaginal Colonization
10:19

A Murine Model of Group B Streptococcus Vaginal Colonization

Published on: November 16, 2016

14.4K
Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
11:07

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans

Published on: December 19, 2014

12.7K
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.4K

科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 传染性疾病 传染性疾病

背景情况:

  • 乙组链球菌 (GBS) 是新生儿侵袭性感染的主要原因.
  • GBS的囊血清型III克隆复合体17 (CC17) 是一种高毒性克隆,与新生儿脑膜炎密切相关.
  • 巨细胞作为一个允许的细胞内的GBS生存.

研究的目的:

  • 为了研究高病毒性GBS CC17菌株和巨之间的特定相互作用.
  • 阐明GBS CC17与宿主免疫细胞增强相互作用的机制.

主要方法:

  • 通过人类单细胞和巨细胞对GBS CC17和非CC17菌株细胞的比较分析.
  • 研究HvgA蛋白和PI-2b柱 (Spb1) 在GBS CC17粘附中的作用.
  • 通过使用抑制剂 (fucoidan, poly ((I)) 评估清除剂受体参与.
  • 细胞内细菌生存和退出机制的分析.

主要成果:

  • 与非CC17菌株相比,GBS CC17菌株表现出显著更高的粘附率和巨细胞细胞分解率.
  • 增强的CC17细胞分裂是由表面蛋白HvgA和PI-2b柱体 (Spb1) 介导的,它们与食尸体受体相互作用.
  • 细胞内生存和退出机制在巨细胞内的CC17和非CC17菌株中都相似.

结论:

  • 超病毒性GBS CC17克隆具有独特的能力,可以增强巨细胞的粘附和细胞化.
  • 这种由特定的表面因素驱动的增强相互作用可能有助于GBS CC17在宿主体内的持久性和传播.
  • 了解这些相互作用,可以了解病原性细菌对宿主免疫系统的颠覆.