患有初级夜间尿液浸泡症的儿童的体微观结构异常:DTI研究
Jinqiu Li1, Yang Zhang1, Jing Chen2
1Department of Medical Imaging and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, 300052, China.
European child & adolescent psychiatry
|March 22, 2024
概括
患有初级夜间尿尿症 (PNE) 的儿童表现出体 (CC) 微观结构的差异,影响睡眠和认知. 这些发现突显了PNE中CC异常,特别是在男孩中.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 放射学 放射学是一门学科.
背景情况:
- 初级夜间尿尿症 (PNE) 是一种常见的儿童睡眠障碍,与异常的兴奋机制有关.
- 体 (CC) 对于半球间通信和睡眠-唤醒调节至关重要,发展到成年期.
研究的目的:
- 用扩散张力成像 (DTI) 来研究PNE儿童的体 (CC) 微观结构.
- 为了比较PNE儿童和健康对照 (HC) 之间的CC的DTI指数.
- 探索 CC 微观结构异常与 PNE 的认知功能之间的相关性.
主要方法:
- 使用扩散张力成像 (DTI) 来从CC及其七个子区域提取指数.
- 在患有PNE的儿童之间比较了DTI指数 (n=?) 和健康的孩子 (HC) (n=? ) 的情况.
- 分析了CC DTI指数和认知评估 (全智商,一般知识记忆) 之间的相关性.
主要成果:
- 与HC相比,患有PNE的儿童在CC的后部中体中表现出纤维数量减少 (NF) 和分数异构 (FA) 的情况.
- 在患有PNE的儿童中,在CC的后部中体和峡谷中观察到辐射扩散率 (RD) 的增加.
- 在患有PNE的男孩中,FA的减少更为明显. NF和FA与完全智商和一般知识记忆相对应,分别为正相关.
结论:
- 这项研究提供了神经成像证据,证明了PNE儿童的CC微观结构异常.
- 在CC微观结构的异常,特别是在男性PNE患者中,可能会影响认知表现.
- 研究结果表明,在PNE中,CC完整性和睡眠唤醒调节之间存在潜在的联系.
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