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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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三甘油糖指数和内皮功能障碍之间的关联

Yan Li1, Ming Yi1, Xinyi Wang1

  • 1Department of Geriatrics, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing, 100053, China.

Endocrine
|March 22, 2024
PubMed
概括

甘油三糖 (TyG) 指数与内皮功能障碍有关,内皮功能障碍是心血管问题的前体. 这种关联在没有糖尿病的个体中尤为明显,突出显示了该指数.

关键词:
内皮质功能障碍 内皮质功能障碍流介导扩张的流介导扩张胰岛素耐药性 胰岛素耐药性是一种三甘油三糖指数是指三甘油三糖的含量.

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科学领域:

  • 心血管医学 心血管医学
  • 内分泌学 在内分泌学.
  • 代谢综合征研究 代谢综合征研究

背景情况:

  • 三甘油-葡萄糖 (TyG) 指数是胰岛素抵抗 (IR) 的公认指标.
  • 之前的研究发现,TyG指数是动脉损伤和心血管事件的预测指标.
  • 泰格指数与内皮功能障碍之间的关系需要进一步研究.

研究的目的:

  • 检查TyG指数与内皮功能障碍之间的关联.
  • 为了确定TyG指数是否可以预测内皮功能障碍.

主要方法:

  • 使用流介导扩张 (FMD) 来评估内皮功能.
  • 840名参与者在2016年10月至2020年1月期间接受了口病测量.
  • 用公式计算TyG指数:Ln [禁食甘油三 (mg/dL) ×禁食血葡萄糖 (mg/dL) /2].

主要成果:

  • 观察到TyG指数和口疾病值之间存在统计学意义上的相关性 (P=0.022).
  • 泰格指数的增加与口病的减少有关,这表明内皮功能障碍 (β=-0.330,P=0.020).
  • 在特定的子组中,这种关联是显著的:年龄在60岁以下的个体,女性和没有糖尿病的人.

结论:

  • 提升的TyG指数与更高的内皮功能障碍的可能性有关.
  • TyG指数是内皮功能障碍的重要预测指标,特别是在非糖尿病人群中.
  • 这些发现强调了TyG指数在评估心血管风险方面的临床相关性.