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Updated: Jun 30, 2025

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
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异常的非正规NF-κB信号重新编程表观基因组格局,以驱动多发性骨髓瘤中的瘤转录组

Daniel A Ang1, Jean-Michel Carter1, Kamalakshi Deka1

  • 1School of Biological Sciences (SBS), Nanyang Technological University (NTU), 60 Nanyang Drive, Singapore, 637551, Singapore.

Nature communications
|March 22, 2024
PubMed
概括

多发性骨髓瘤中异常的非正规NF-κB信号通过重编程表观基因组驱动癌症的进展. 这项研究确定了p52依赖增强剂和RGS1作为关键驱动因素,揭示了新的治疗点.

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