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Updated: Jun 30, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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p53调节小鼠内源性DNA损伤的各种组织特异性结果

Ross J Hill1, Nazareno Bona1, Job Smink2

  • 1MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge, UK.

Nature communications
|March 22, 2024
PubMed
概括

细胞对DNA损伤的反应,而不仅仅是DNA修复,决定了特定组织的结果. 瘤抑制剂p53 (编码为TP53) 在不同的组织中起着不同的作用,影响DNA修复缺陷的疾病进展.

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