单个异常值的葡萄糖耐受性测试作为2型糖尿病的预测:一个多中心的回顾性研究
Seon Ui Lee1, Subeen Hong2, Sae Kyung Choi1
1Department of Obstetrics and Gynecology, College of Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea.
在怀孕期间测试葡萄糖的单个异常值 (SAV),而不仅仅是孕期糖尿病 (GDM),显著增加了产后2型糖尿病 (T2DM) 和不良妊娠结果的风险.
科学领域:
- 内分泌学 在内分泌学.
- 产科 产科 产科 产科 产科
- 周围生理学 周围生理学
背景情况:
- 怀孕期间100克口服葡萄糖耐受性测试中单个异常值 (SAV) 的临床意义尚不清楚.
- 妊娠期糖尿病 (GDM) 是一种已知的产后2型糖尿病 (T2DM) 的风险因素.
研究的目的:
- 评估SAV妇女产后T2DM的风险.
- 调查与SAV相关的不良妊娠结果.
主要方法:
- 从七个韩国医疗中心的数据进行了回顾性分析.
- 在使用卡特-库斯坦标准的正常血糖,SAV和GDM组中比较怀孕和产后结果.
- 多变量分析以确定产后T2DM的危险因素.
主要成果:
- 与正常血糖组相比,SAV和GDM组的产后T2DM发病率显著更高 (7.60%,14.83%,1.82%,p<0.001).
- 与正常血糖组相比,SAV组显示出与怀孕相关的高血压,早产和新生儿低血糖/败血症的增加率.
- 产后T2DM与SAV,GDM,无双性,怀孕前BMI,慢性高血压,高脂血症和DM家族病史有关.
结论:
- 孕期血糖检测中的单个异常值 (SAV) 是产后2型糖尿病 (T2DM) 的重要危险因素.
- SAV还与不良妊娠结果有关,包括高血压,早产和新生儿并发症.
- 5年内产后T2DM的预测模型显示中度准确性 (AUC=0.74).
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