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Updated: Jun 30, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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丢失RNA结合蛋白CELF2通过FAT10-mTORC1促进急性白血病的发展

Tengxiao Guo1,2,3, Yuxia Wang1, Xiaolu Sun1

  • 1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.

Oncogene
|March 22, 2024
PubMed
概括

失去了CELF2蛋白增强了造血干细胞的自我更新,并通过稳定FAT10mRNA加速了急性髓性白血病 (AML) 的发展. 针对CELF2/FAT10-AKT/mTORC1通路提供了AML抑制的潜力.

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