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肠道微生物群与非洲裔美国大学运动员的血压状况有差异相关:试点研究
Taylor Hogue1, Jarrad Hampton-Marcell2, Ian M Carroll3
1Department of Kinesiology, North Carolina Agriculture and Technical State University, Greensboro, North Carolina, USA.
Physiological reports
|March 22, 2024
概括
高血压在运动员中很常见,尤其是非洲裔美国人. 这项研究在黑人大学运动员中发现了与高血压 (BP) 相关的特定肠道微生物,这表明肠道微生物在运动高血压中发挥了作用.
科学领域:
- 人类生理学 人类生理学
- 微生物组研究的研究.
- 心血管健康的心血管健康
背景情况:
- 高血压 (HTN) 在运动员中普遍存在,非裔美国人 (AAs) 的心血管 (CV) 突然死亡率更高.
- 肠道微生物失调与久坐不动的人群中HTN有关,但其在HTN运动员中的作用尚不清楚.
- 了解这些差异对于运动群体的有针对性的健康干预至关重要.
研究的目的:
- 研究和区分与非裔美国大学运动员血压 (BP) 状态相关的肠道微生物特征.
- 在这个人口群体中确定与高血压相关的特定微生物属.
- 为未来研究这些微生物在运动血压调节中的功能性作用奠定基础.
主要方法:
- 研究包括30名非洲裔美国大学运动员,分为正常血压 (n=15) 和HTN (n=15) 两组.
- 用16S rRNA基因测序分析了便样本,以确定基因层面的微生物组成.
- 统计分析包括α和β多样性测量,与PERMANOVA进行主要坐标分析 (PCoA),以及斯皮尔曼等级相关性.
主要成果:
- 在正常BP和HTN组之间没有观察到α多样性的显著差异.
- 贝塔多样性在各组之间有显著差异,表明不同的微生物社区结构 (PERMANOVA,p < 0.05).
- 综合性血压显示与阿德勒克鲁齐亚,科普罗科克,格拉努利卡特拉和维龙内拉的丰富度有显著的正相关性.
结论:
- 肠道微生物概况与非洲裔美国大学运动员的血压状况有关.
- 特定的微生物属 (Adlercreutzia,Coprococcus,Granulicatella,Veillonella) 与这一群体的高血压有关.
- 这些发现突出了肠道微生物组在运动员高血压中的潜在作用,并指导了未来的功能研究.
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