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计算机断层扫描量化的呼吸肌肉与慢性阻塞性肺病之间的关联:一项回顾性研究

Ke Wang^1,2, Fan Wu³, Hua He¹

¹Department of Infectious Diseases, Respiratory and Critical Care Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.

BMC pulmonary medicine

|March 22, 2024

概括

胸部肌肉的大小,特别是大胸部,与慢性阻塞性肺部疾病 (COPD) 有关. 患有COPD的患者胸部主要肌肉区域较大与急性恶化较少相关 (AECOPD).

科学领域:

肺部医学肺部医学
放射学放射学是一门学科.
人体解剖学解剖学解剖学

背景情况:

慢性阻塞性肺病 (COPD) 是一种渐进的肺病.
胸部肌肉的组成及其与COPD严重程度和恶化相关性尚未得到充分了解.
调查胸部肌肉区域和COPD之间的关系对于了解疾病进展和患者结果至关重要.

研究的目的:

检查胸部肌肉区域与慢性阻塞性肺病 (COPD) 之间的关联.
调查胸部肌肉区域与COPD急性恶化 (AECOPD) 的频率之间的关系.

主要方法:

使用3D Slicer软件分析了269名受试者的计算机断层扫描 (CT) 扫描 (101名COPD患者,168名非COPD对照).
测量了各种呼吸道和辅助呼吸道肌肉的区域,包括大胸部.
单变量和多变量Poisson回归和接收器运行特征 (ROC) 曲线被用于分析与AECOPD的关联.

主要成果:

与非COPD组相比,患有COPD的患者表现出明显较小的肌肉区域,包括大胸部,小胸部,腹膜,前和肋间肌肉.
胸部主要肌肉区域显示ROC曲线下的最高区域 (81.56%),表明具有强大的诊断潜力.
更大的胸部主要肌肉区域与前一年的AECOPD数量有负相关性 (RR,0.936;P=0.037).

结论:

胸部主要肌肉区域的缩小与COPD有关.
胸部主要肌肉区域与COPD患者急性恶化频率有负相关性.
胸部肌肉测量,特别是大胸部,可以作为COPD严重程度和恶化风险的潜在生物标志物.

关键词:

辅助呼吸道肌肉辅助呼吸道肌肉慢性慢性肺炎是一种慢性慢性肺炎,COPD是一种慢性肺炎.这就是为什么CTCTCTCTCTCT 大胸主要的胸部.

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