年龄和阿波利波蛋白E ε4状态对区域白质高强度体积和健康衰老中的认知能力的影响
Emily J Van Etten1,2, Pradyumna K Bharadwaj1,2, Matthew D Grilli1,2,3
1Department of Psychology, University of Arizona, Tucson, AZ, USA.
概括
在年轻的老年人中,APOE ε4等位基因与左白质高强度 (WMH) 量增加有关,这可能预测认知衰老和阿尔茨海默病风险.
科学领域:
- 神经成像是一种神经成像.
- 神经退行发生神经退行.
- 认知老龄化 认知老龄化
背景情况:
- 白质高强度 (WMH) 体积是小血管疾病的标志物.
- WMH与认知衰老和阿尔茨海默病 (AD) 风险有关.
研究的目的:
- 调查区域WMH体积是否调解了APOE ε4状态和认知之间的关系.
- 为了检查年龄组的差异是否能缓和这种关联.
主要方法:
- 研究包括187名健康的老年人 (56名e4携带者,131名非携带者).
- 检查了APOE ε4状态,区域WMH体积和认知功能.
- 对性别,教育和血管风险因素进行控制.
主要成果:
- 根据APOE ε4相互作用的显著年龄组,用于右顶部和左部WMH体积.
- 在年轻的老年人中,e4载体具有更大的WMH;这在老年人中没有观察到.
- 左WMH调解了e4状态对年轻老年人认知的影响.
结论:
- 在年轻老年 ε4 载体中,左WMH 增加可能是认知衰老的早期标志物.
- 这一发现表明,阿尔茨海默病风险增加的潜在途径.
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