在用凝配方进行局部注射治疗时减少逆流
Kazuki Kotani1, Francois Marie Ngako Kadji1, Yoshinobu Mandai1
1Department of Biomedical, R&D C-enter, Nitta Gelatin, Inc, Yao City, Osaka, Japan.
Drug delivery
|March 22, 2024
概括
凝颗粒和水解凝有效地减少局部药物注射期间的逆流. 这项研究表明,在各种组织模型中,最佳的度和颗粒大小可以最大限度地减少材料泄漏.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 最少侵入性手术的方法
背景情况:
- 局部注射实现了高药物暴露,但存在物质回流和副作用的风险.
- 优化局部注射技术对于治疗疗效和患者安全至关重要.
研究的目的:
- 调查基于凝的配方在局部注射期间减少回流的有效性.
- 确定最佳的凝颗粒大小,度和分子重量,以最大限度地减少反流.
主要方法:
- 在组织模型 (VTT,VTT-T,BCM) 中注射了凝颗粒 (GPs) 和化凝 (HG),使用各种针尺 (23G-33G).
- 使用过纸测量回流流量,以量化材料泄漏.
- 对不同的凝配方和度的注射性和逆流减少进行了评估.
主要成果:
- 在35μm GPs (高达5%度) 和75μm GPs (高达2%度) 观察到显著的回流减少.
- 水解凝的有效性取决于分子量,较低的分子量需要更高的度 (5-30%),较高的分子量需要更低的度 (7-8%).
- 发现最佳的凝度和粘度是防止各种注射体积和组织类型的逆流的关键因素.
结论:
- 基于凝的配方,特别是优化的凝颗粒和化凝,有效地减少局部注射中的材料回流.
- 这些发现表明,精确控制凝度,颗粒大小和粘度可以提高局部药物输送的安全性和有效性.
- 需要进一步的研究来探索这些凝配方与活性治疗剂用于器官和瘤注射的应用.
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